Gene Expression Profiling in Breast Cancer

Breast cancer is a complex genetic disease characterized by the accumulation of multiple molecular alterations. Today, routine clinical management of breast cancer is insufficient to reflect the whole clinical heterogeneity of this disease. Recent advances in human genome research and gene expression profiling have made it possible to start uncovering biological mechanisms underlying clinically useful signatures. Here we highlight gene expression profiling in breast cancer research and discuss its most current clinical applications.