Family history of premature coronary heart disease and risk prediction: the authors’ reply

The Authors' reply We recently reported in an analysis of the EPIC-Norfolk cohort that a family history of premature coronary heart disease and risk prediction (CHD) was an independent risk factor for future CHD events.1 However, its use did not improve the classification of people into risk categories based on the Framingham Risk Score. We read with interest the comment by Nadir and Struthers2 who urge us to perform two additional analyses. The …