Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis Running title Bortezomib suppresses plasmacytoid DC

Department of Dermatology and Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Japan Science and Technology Agency, CREST, Tokyo, Japan; Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Island and Community Medicine, and Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan