A pilot study on the diagnostic value of high resolution microendoscopy for colorectal cancer

Objective 　To summarize the image feature of normal colorectal mucosa and colorectal cancer tissues based on high-resolution microendoscopy (HRME), and evaluate the feasibility of HRME in the diagnosis of colorectal cancer. Methods 　Twelve colorectal cancer surgical specimens confirmed by pathology and 56 biopsy specimens from colorectal lesions by conventional endoscopy were selected for the study. The normal mucosa and colorectal cancer tissue were imaging-observed to establish the HRME-diagnostic criteria of the normal mucosa and colorectal cancer tissues taking pathological diagnosis as the gold standard. According to the established criteria, the 56 biopsy specimens of colorectal lesions were HRME-imaged, and the prediagnosis was made. The prediagnosis result was compared with the pathological results for evaluating the diagnostic value of HRME. Results 　In the prospective study of 56 colorectal lesion specimens, 25 patients were diagnosed with cancer by HRME, of which 21 cases were confirmed by pathological examination. 31 specimens were diagnosed as non-cancerous tissues by HRME, and 29 were confirmed by pathology. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of HRME in diagnosis of colorectal cancer were 91.3%, 87.9%, 89.3%, 84.0%, 93.5% respectively. The Kappa value was 0.78. Conclusions 　HRME can distinguish cancerous lesion from non-cancerous colon tissue, and have good consistency with pathological diagnosis, thus is of good prospects in terms of guidance for biopsy and diagnosis of colon cancer. DOI: 10.11855/j.issn.0577-7402.2016.09.09