Successful Lysis of Thrombus with Tissue Plasminogen Activator in a Bidirectional Glenn on Venoarterial Extracorporeal Life Support

This case study reports a seven month male who was cannulated for venoarterial extracorporeal life support for hypoxemia due to thrombosis of the bidirectional Glenn circulation. He received low dose tissue plasminogen activator (tPa) (0.03 mg/kg/hr) on ECLS with complete thrombolysis. tPa infusion was complicated by mediastinal bleeding.