The novel Ideal Symmetry Genetic Code table - Common purine-pyrimidine symmetry net for all RNA and DNA species.

Abstract Ever since Nirenberg’s discovery in 1961 in which codons code individual amino acids, numerous scientists searched for symmetries within the genetic code. The standard genetic code (SGC) table is an alphabetic artificial construct based on the U-C-A-G ordering of nucleotides without natural symmetries. Up to the present, complete symmetry in the genetic code has not been found, leaving doubt as to whether the symmetrical nature as the protector of order even exists. Our novel Ideal Symmetry Genetic Code (ISyGC) table reflects a unique fundamental physicochemical purine-pyrimidine symmetry net for all more than thirty known variations of nuclear and mitochondrial genetic codes. The nuclear genetic code for RNA and DNA viruses also contains the same purine-pyrimidine symmetry net. We show that the ISyGC table leads to automatic transformation into a DNA sequence akin to the 5’3 codon and 3’5 anticodon patterns. As a result of purine-pyrimidine symmetries between codons in the ISyGC table, algorithms of the first two bases as well of the third base of codons show how tRNA cognate anticodons can recognize synonymous codons during mRNA decoding. We show that the ISyGC purine-pyrimidine net with its physicochemical properties represents an evolutionary common “frozen accident” at the onset of each genetic code creation and RNA to DNA evolution. As such, during all of evolution the unique fundamental purine-pyrimidine symmetry net of all genetic codes remains unchangeable. In this way, evolution is a road paved with symmetries.