Utilization of a compaction simulator to formulate mini-tablets containing high dose of acyclovir

Abstract In this research, compaction simulator was utilized to develop high drug-loaded minitablet formulation. The formulation factors (type and ratio of filler, lubricant amount) and process factors (compression pressure, compression rate) were adjusted and the ejection force, tensile strength, thickness, compression energy, and elastic energy of mini-tablet were evaluated. The pregelatinized starch was found to be suitable base filler based on its ejection force reducing ability. When the high level of lubricant was used, tensile strength was negatively affected due to the hindrance effect. The compression pressure and compression rate influenced the ejection force by engaging in the residual die wall stress and mobility of lubricant. Meanwhile, investigation on the energy values suggested the high elasticity of pregelatinized starch. The optimized formulation could produce mini-tablets with acceptable ejection force, mechanical strength, aspect ratio, and release profile within the wide range of compression pressure and compression rate.