The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model

Chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults, is characterized by an accumulation of monoclonal B cells with a mature phenotype in the blood and lymphoid organs. Despite considerable advances in the treatment of patients, CLL remains an incurable disorder,[1][1],[2][2]