Enhancement of ANTI-HSV-1 activities using liposomes with naphthoquinones

Today almost 67% of individuals with age up to 49 years are infected with HSV-1 and 50% of them, with age between 15-49, are infected with genital HSV-1. Naphthoquinones derivatives synthetized by Mannich base derived possess an efficient ability to control in vitro herpesvirus replication. Liposomes are drug delivery systems able to lower the concentrations in order to reduce the toxicity.