The concurrence of multiple sclerosis and glioblastoma.

Abstract Introduction : Glioblastoma rarely coincides with multiple sclerosis. Although registries have reported a higher proportion of brain tumors—most of which are glial—these events appear to be underreported. The relative contribution of JC virus (an oncogenic virus) and disease modifying therapies that may facilitate JC virus neurotropism and tumor-specific immune evasion remain unknown. Case Report : We present the case of a 64-year-old woman who developed a primary glioblastoma eight years after diagnosis of multiple sclerosis while on dimethyl fumarate. Conclusion : Systematic reporting may help answer whether JC virus seropositivity and certain disease modifying therapies confer higher risk for glioblastoma in patients with multiple sclerosis.