A method for preparation of intermediate inhibitor nep

The present invention discloses a method for preparing NEP inhibitor intermediates, discloses a neutral endopeptidase (NEP) inhibitors intermediate (2R, 4S) -5 - ([1,1'- biphenyl] 4-yl) -4 - ((tert-butoxycarbonyl) amino) -2-methylpentanoic acid chiral ligand in the presence of a reducing selectively prepared. A method for specifically includes in the presence of a transition metal catalyst and a chiral ligand with hydrogen diastereomeric stereoselective hydrogenation synthesis. The metal catalyst used in the present invention is inexpensive, readily available chiral ligand, with high yield and preferably produces a product with high purity, preferably a non-generating enantiomeric ratio of the product is higher than 90:10.