Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms

Staphylococcus aureus biofilms are a significant problem in healthcare settings, in part, owing to the presence of a non-dividing, antibiotic tolerant sub-population. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against non-dividing Staphylococcal spp HT61 was effective in reducing biofilm viability, associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.