Copper-catalyzed selective radical–radical cross-coupling for C–S bond formation: an access to α-alkylthionitriles
2018
A new protocol for C–S bond formation was developed by selective cross-coupling between a thiyl radical and an isobutyronitrile radical. Using this strategy, a series of valuable α-alkylthionitrile derivatives were synthesized from basic starting materials. Preliminary mechanistic investigation was performed by EPR and XAFS, revealing that the transient thiyl radical could be stabilized by a copper catalyst to a persistent one. Therefore, on the basis of the persistent radical effect, selective radical–radical cross-coupling between the thiyl radical and the isobutyronitrile radical was achieved successfully in this work.
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