Enhanced Stability and Knockdown Efficiency of Poly(ethylene glycol)-b-polyphosphoramidate/siRNA Micellar Nanoparticles by Co-condensation with Sodium Triphosphate

Purpose Polyelectrolyte complex nanoparticles are a promising vehicle for siRNA delivery but suffer from low stability under physiological conditions. An effective stabilization method is essential for the success of polycationic nanoparticle-mediated siRNA delivery. In this study, sodium triphosphate (TPP), an ionic crosslinking agent, is used to stabilize siRNA-containing nanoparticles by co-condensation.