Synthesis of Certain 3-Pyridyl (1,2,4) Triazolo (3,4-B) (1,3,4) Thiadiazepines and Evaluation of their Possible Biological Activities

An environmentally benign and economic synthesis of 3-pyridyl [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazepines is described from readily accessible substituted 2-mercapto-1-amino triazoles and substituted chalcones in the presence of glacial acetic acid and ethanol by exposure to heat for 3-4 hrs. Identification of the new compounds was established by IR, HNMR and MASS spectral data. All the synthesized compounds were tested for their in vitro antibacterial, antifungal and anti-tubercular activities. Most of the compounds showed significant antimicrobial properties. The best activity was observed with compounds 4a, 4c, 4d, 4e, 4g, 4h, 4i & 4j.