(E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice

Yayoi Saegusa,Chiharu Sadakane,Junichi Koseki,Yoshihiro Hasegawa,Shoichiro Shindo,Shuichi Takeda,Hiroshi Takeda,Tomohisa Hattori

(E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice

2010

Yayoi Saegusa
Chiharu Sadakane
Junichi Koseki
Yoshihiro Hasegawa
Shoichiro Shindo
Shuichi Takeda
Hiroshi Takeda
Tomohisa Hattori

Background TJN-331 is an inhibitor of transforming growth factor β1 (TGF-β1) production that has similar structural features to the natural product acteoside. This study was performed to examine the antinephritic effects of TJN-331 in a mouse model of experimental IgA nephropathy.

Keywords:

Mesangial expansion
Internal medicine
Concanavalin A
Endocrinology
Mesangium
Oral administration
Nephropathy
Transforming growth factor
Diabetes mellitus
Medicine
2-Propenamide
Mononuclear phagocyte system
Creatinine
Antibody
Captopril

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