Short-term curative effect of the optional time of cancer prophylactic cranial irradiation for limited-stage small cell lung

Objective To observe the impact of brain metastasis rate and effect on survival in limited-stage small cell lung cancer (LSCLC) patients who received the prophylactic cranial irradiation (PCI) within time cause after alternate chemoradiotherapy of complete response (CR). Methods Data from 47 patients with LSCLC who were divided into two groups according to the different forms of as observation group 1 (n=25) and observation group 2 (n=22) were retrospective analyzed. The patients in both groups received EP chemotherapy for 2 cycles and chest radiation therapy, while the patients of the observation group1 repeated to other 2 cycles of EP and then PCI, and the observation group 2 for 4 cycles with the same radiation dose and consistent way. Results Brain metastasis rate of the observation group1 was 20.00 % (5/25) and that of the observation group 2 was 18.18 % (4/22) in the past three years (P=0.431). The median survival time of the observation group 1 was 16 months (95 % CI 12.945-19.055), and the 1-, 2-and 3-year survival rates were 76 %, 26 % and 16 %, respectively. The median survival time of the observation group 2 was 17 months (95 % CI 6.796-27.204), and the 1-, 2-and 3-year survival rates were 53 %, 38 % and 16 %, respectively. Two groups of there was no survival difference (P=0.920). There was also no significant difference in Local progression-free survival and systemic metastases between both groups (P=0.706, P>0.05, respectively). Conclusion Different time to begin receiving the PCI dose not affect the recent brain metastasis rate and overall survival rates. Key words: Small cell lung cancer; Prophylactic cranial irradiation; Brain metastasis