Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
2008
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
Keywords:
- Internal medicine
- Synaptic plasticity
- Endocrinology
- Metabotropic glutamate receptor 3
- Cell biology
- Long-term depression
- Metaplasticity
- Metabotropic glutamate receptor
- Metabotropic glutamate receptor 1
- Anesthesia
- Metabotropic glutamate receptor 8
- Synaptic fatigue
- Biology
- Metabotropic glutamate receptor 7
- Metabotropic glutamate receptor 5
- Neuroscience
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