Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex

Piotr Wysoczanski,Cornelius Schneider,ShengQi Xiang,Francesca Munari,Simon Trowitzsch,Markus C. Wahl,Reinhard Lührmann,Stefan Becker,Markus Zweckstetter

Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex

2014

Piotr Wysoczanski
Cornelius Schneider
ShengQi Xiang
Francesca Munari
Simon Trowitzsch
Markus C. Wahl
Reinhard Lührmann
Stefan Becker
Markus Zweckstetter

A solution NMR structure of the pre-mRNA retention and splicing (RES) core complex from budding yeast now reveals how the trimer stabilizes the RRM of its Snu17 subunit to promote pre-mRNA interactions within the spliceosome.

Keywords:

Precursor mRNA
Spliceosome
Trimer
RNA-binding protein
RNA splicing
Molecular biology
Heterotrimeric G protein
Saccharomyces cerevisiae
Protein subunit
Biology

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