Effect of Fu Zheng Kang Ai Fang,a Chinese medicine,on implanted hepatoma in rats

AIM: To establish the implanted hepatic cancer models in SD rats,and to observe the effects and mechanism of Fu Zheng Kang Ai Fang on implanted hepatoma models.METHODS: Walker256 carcinoma was implanted to the liver of SD rats.The rats were treated with low-dose,medium-dose and high-dose Fu Zheng Kang Ai Fang respectively.The vital signs and the survival time were recorded.Arterial blood was collected at time points of 1 week,2 weeks and 3 weeks after transplantation to measure the levels of lanineamino-transferases(ALT),aspartateamino-transferases(AST),aspartateamino-transferases: alanineamino-transferases(S/L),albumin(ALB),albumin/globulin(A/G),alkaline phosphatase(ALP),γ-glutamyl transferase(GGT) and alpha-L-fucosidase(AFU).RESULTS: The values of the ALT,AST in high-dose and medium-dose Fu Zheng Kang Ai Fang groups were less than those in hepatoma model group(P0.01),and the values of ALB and A/G were more than those in hepatoma model group(P0.05) at 3 weeks.The values of ALP,GGT and AFU in high-dose Fu Zheng Kang Ai Fang group decreased(P0.01).The median survival rate of low-dose,medium-dose and high-dose Fu Zheng Kang Ai Fang groups increased,which were longer than that in model group.CONCLUSION: Herbal Mixture Fu Zheng Kang Ai Fang improves the quality of life and prolongs the survival time of implanted hepatoma rats.Fu Zheng Kang Ai Fang protects the liver functions,including the decrement of the ALT and AST,maintenance of the ALB level,and reduction of the hepatoma indicating enzyme like the ALP,GGT and AFU.The results show that the high-dose Fu Zheng Kang Ai Fang is the best mixture.