Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands
2008
A series of estrogen receptor ligands based on a 3-alkyl naphthalene scaffold was synthesized using an intramolecular enolate-alkyne cycloaromatization as the key step. Several of these compounds bearing a C6-OH group were shown to be high affinity ligands. All compounds had similar ERα and ERβ binding affinity ranging from micromolar to low nanomolar.
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