CpxM(III)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes

CpxM(III)-catalyzed enantioselective C–H functionalization reactions have progressed rapidly using either chiral cyclopentadienyl ligands or appropriate chiral carboxylic acids. In this context, highly reactive carbene and nitrene precursors can serve as effective C–H coupling partners, providing a straightforward and efficient approach to access chiral molecules. In this review, we highlight the developments in CpxM(III)-catalyzed enantioselective C–H functionalization reactions through migratory insertion of metal–carbenes/nitrenes by employing chiral CpxM(III) complexes or achiral CpxM(III) complexes combined with chiral carboxylic acids.