Rapid hydrolysis of amides under physiological conditions: Influence of the microenvironment on the stability of the amide bond
1998
Abstract A new class of bicyclic carboxyamides 1a-9a differing with respect to substitution patterns and exoendo geometry has been synthesized. These amides are characterized by a structure-dependent unusual rapid hydrolysis rate at physiological conditions. The corresponding bicyclic anhydrides might be used as tools for masking and modifiying therapeutic agents containing amine functionalities.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
11
References
3
Citations
NaN
KQI