Pyrimido heterocyclic compounds and pharmaceutical compositions and uses

The present invention discloses a pyrimidine structure (Ⅰ) heterocyclic compounds having the formula and or a pharmaceutically acceptable salt or stereoisomer thereof, or prodrug molecules. The compounds may inhibit the growth of various tumor cells, and EGFR inhibition produced protease, useful for preparing anti-tumor drugs, and drugs can be overcome gefitinib, erlotinib induced resistance and the like, wild non-small cell lung selective, have good pharmacokinetic properties.