Design, synthesis, antibiofilm, quorum sensing inhibition, anticancer and docking studies of novel 2-(4-acridine-9-ylamino)isoindoline-1,3-dione

Abstract A series of novel 2-(4-(acridin 9yl amino)phenyl)isoindoline-1,3-dione derivatives 6a–6j were synthesized and screened for antibiofilm, antiquorum sensing and in-vitro anticancer activity against MCF-7 cell lines. The obtained result indicates that the potent compounds are promising chemical entities for the new class of potential antibiofilm and anticancer drug-like molecules. Further, molecular docking has shown that compounds have good binding affinities with protein and ligands. Whereas, DNA cleavage by gel electrophoresis method revealed that compounds 6g and 6h cleaved the DNA completely.