Investigation of the effect of poorly controlled diabetes mellitus on erythrocyte life

Abstract Erythrocyte half-life ( E t − 1 2 ) has been measured in 11 patients with poorly controlled blood sugar levels and compared with a normal control group to determine whether decreased red cell deformability, which occurs in diabetic patients, causes shortening of erythrocyte life or not. No difference was seen ( E t − 1 2 ) = 28.1 days in diabetic patients and 28.5 days in controls). There was also no correlation between E t − 1 2 and glycosylated hemoglobin (HbA 1 levels. It has been concluded that poorly controlled diabetes mellitus has no effect upon erythrocyte life.