Synthesis and insecticidal activity of novel heptafluoroisopropyl substituted 2,2-difluoro-1,3-benzodioxol-5-acetamide derivatives

In order to discover novel and environmentally benign pesticides, a series of novel heptafluoroisopropyl substituted 2,2-difluoro-1,3-benzodioxol-5-acetamide derivatives were synthesized via amide condensation reaction in aqueous solution. All the title compouds were characterized by 1 H NMR, 19 F NMR and HRMS. The bioassays showed that some of the compounds exhibited good insecticidal activities against bean aphids ( Aphis craccivora ) and armyworms ( Mythimna separata ). Preliminary structure-activity relationship studies suggested that the substituent groups played a key role in the insecticidal activities of the compounds.