ALTERATION OF PEPTIDES IN RAT BRAIN TREATED WITH ANGIOTENSIN-CONVERTING ENZYME INHIBITOR, CAPTOPRIL

Although animal studies suggest that centrally active angiotensin‑converting enzyme (ACE) inhibitors may protect against dementia beyond HTN control the mechanism (s) underlying these improvements in cognitive function remains unclear. We measured the brain peptide levels in rat treated with captopril (50 mg/kg) for 3 weeks by using surface‑enhanced laser desorption/ionization time‑of‑flight mass spectrometry (SELDI TOF‑MS) . Two protein chip arrays were used for peptide profi ling: one with a strong anion‑ exchanger and the other with a weak cation‑exchanger. Comparing with control group 15 mass peaks were considered specifi c to experimental animals and 6 peaks were signifi cantly up‑regulated and 5 down‑regulated. Hirosaki Med.J.　61 Supplement:S252―S254,2010