Optimization of ionic liquid based ultrasonic assisted extraction of antioxidant compounds from Curcuma longa L. using response surface methodology

Abstract In this paper, response surface methodology was employed to optimize experimental process for ionic liquid based ultrasonic assisted extraction of curcuminoids compounds from rhizomes of Curcuma longa L. The Box–Behnken design on three factors and five levels together with response surface methodology were used to optimize experimental conditions for total curcuminoids content and radical scavenging capacity. The radical scavenging capacity was determined by ABTS and TRAP methods. For the ionic liquid based ultrasonic assisted extraction, optimum process was set as below: [Omim]Br concentration, 4.2 mol/L; liquid-raw ratio, 30 mL/g; extraction time, 90 min; ultrasonic power, 250 W.