Synthesis of novel pyrimido[4,5-c]pyridazines and 1,2-dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-ones as potent inhibitors of lymphocyte specific kinase (LCK)
2006
This paper details the synthesis of a novel class of 1,2-dihydro-pyrimido[4,5-c]pyridazines and substituted 1,2-dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-one. The most potent analogs disclosed showed low nanomolar activity for the inhibition of lck kinase.
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