Эффективность карведилола в комплексной терапии больных артериальной гипертонией и ишемической болезнью сердца в сочетании с сахарным диабетом 2 типа

Aim. To assess carvedilol effectiveness in patients with coronary heart disease (CHD) and arterial hypertension (AH), with or without associated diabetes mellitus (DM). Material and methods. The study included 27 participants with mild to moderate AH and effort angina of various functional classes. Thirteen patients also had DM in anamnesis. Carvedilol was administered in initial dose of 6,25-12,5 mg/d. At baseline and in the end of the study, clinical status, blood biochemistry, and 24-hour ECG monitoring data were analyzed. Results. In patients with or without DM, regular carvedilol therapy facilitated significant decrease in heart rate, blood pressure, microalbuminuria, frequency and duration of pain and silent ischemia episodes with various rhythm disturbances. Carvedilol therapy was not associated with substantial metabolic disturbances. Conclusion. Carvedilol was effective in complex CHD and AH treatment among DM patients.