Synthesis and Anticancer Activity of New Pyridine-Thiophene andPyridine-Furan Hybrid Compounds, Their Sugar Hydrazone, and GlycosylDerivatives
2020
New sugar hydrazones and their derived oxadiazolyl acyclic nucleoside analogs
in addition to the derived thioglycosides incorporating pyridine, furan or
thiophene have been synthesized via a multi-component reaction (MCR). The
acetylated derivatives of hydrazones and the derived deprotected thioglycosides
of the prepared acetylated analogs have been also synthesized. Anticancer
activity of the products has been tested against adenocarcinomic human alveolar
basal epithelial (A549), human prostatic adenocarcinoma (PC3) and human
colorectal carcinoma (HCT116) cell lines in addition to their effect on human
normal retinal pigmented epithelial cell line (RPE1) using the MTT assay. Three
products: acid hydrazide, sugar hydrazine and glycoside are characterized by
high activity against three cancer cell lines.
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