Processes for production of (r)-3- 4-(trifluoromethyl)- phen ylamino pentanamide derivatives
2004
The present invention provides a method for easily
producing an
(R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide
derivative useful for an intermediate for pharmaceutical
products, particularly an inhibitor of a cholesteryl ester
transfer protein (CETP) from easily available raw materials. In the present invention,
(S)-N-[4-(trifluoromethyl)phenyl]-3-hydroxypentanoic acid
amide prepared from easily available raw materials leads a
production of
(R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone to
give (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid
amide. Furthermore,
(R)-4-ethyl-1-[4-(trifluoromethyl)phenyl]-2-azetidinone is
reacted with a carbamic acid ester to give an
(R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide
derivative.
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