Coinfections of influenza and other respiratory viruses are associated to children

Abstract Introduction Coinfections of influenza and other respiratory viruses (ORVs) are frequent in the epidemic season. The aim of this study was to examine the demographic and virological variables associated with coinfections by influenza and ORVs. Materials and methods We analysed respiratory samples of patients with laboratory-confirmed influenza using molecular diagnostic methods obtained in 8 consecutive influenza seasons (2011–2012 to 2018–2019). We analysed data focusing on different variables: age, sex, type of patient (hospitalized/sentinel) and detected type/subtype of influenza. Results Coinfections of influenza and ORVs were detected in 17.8% of influenza-positive samples. The probability of detecting coinfection was significantly higher in young children (0–4 years; OR: 2.7; 95% CI: 2.2–3.4), children (5–14 years; OR: 1.6; 95% CI: 1.2–2.1) and patients infected with the A(H3N2) subtype (OR: 1.4; 95% CI: 1.14–1.79). Also, we found a significantly higher frequency of coinfections involving influenza and 2 or more other respiratory viruses in young children (0–4 years; OR: 0.5; 95% CI: 0.32–0.8), adults (40–64 years; OR: 0.5; 95% CI: 0.3–0.9) and women (OR: 0.7; 95% CI: 0.5–0.9). Discussion These results show that coinfections of influenza and ORVs are more frequent in young children and children, and in cases involving the A(H3N2) influenza subtype. Our findings can be useful to guide the use of multiplex diagnostic methods in laboratories with limited resources.