Seminal plasma miRNA marker associated with human non-obstructive azoospermia and application thereof

The invention belongs to the field of reproductive medicine and genetic engineering, it discloses seminal plasma microRNA markers and application of human non-obstructive azoospermia related. The marker is selected from hsa-miR-141, hsa-miR-193a-5p, hsa-miR-590-5p, hsa-miR-7-1 * of more. The marker has a specificity and sensitivity of the non-obstructive azoospermia, agents useful in the preparation of non-obstructive azoospermia diagnosis or monitoring can be avoiding invasive diagnosis, detection can be repeated, easy and dynamic monitoring spermatogenesis disorders degree.