微波辐射下AlCl3•6H2O催化合成β-烯胺酮

Aim To research the method for microwave-assisted synthesis of β-enaminones. Methods Using AlCl3•6H2O as catalyst, the reaction of acetylacetone or 1, 3-dioxocyclohexane and amines was processed under microwave radiation from 1 min to 20 min to give the corresponding β-enaminones under solvent-free condition. Results The structure of the compounds was confirmed by IR, 1H NMR and elementary analysis. The yield of the target is 80%~99%. Conclusion The methods were mild, simple and available for synthesis of β-enaminones in good yields without use of solvent.