Chemoprevention of Oral Cancer

Oral squamous cell carcinoma (OSCC) afflicts an estimated 500,000 patients annually worldwide (1,2). Oral carcinoma incidence is increasing in developing countries (1,3), substantially among younger people (4, 5, 6). Of note, patients with oral cavity cancer have an increased risk of acquiring a second primary cancer in other parts of the upper aerodigestive tract, such as the bronchial tree and esophagus (7).