Silver-mediated radical phosphorylation/cyclization of N-allylbenzamides to access phosphoryl-substituted dihydroisoquinolones

A silver-mediated phosphorylation/cyclization of N-allylbenzamides with phosphine oxides for the synthesis of phosphoryl-substituted dihydroisoquinolones was developed. This protocol features broad substrate scope, experimental simplicity, high efficiency, step-economy, and facile scalability.