Noninvasive Neurally Adjusted Ventilatory Assist in Premature Infants Postextubation

Background  Neurally adjusted ventilatory assist (NAVA) has distinct advantages when used invasively compared with conventional ventilation techniques. Evidence supporting the use of noninvasive NAVA is less robust, especially in the very low birth weight (VLBW) population. Objective  To determine whether synchronized noninvasive ventilation via neurally adjusted ventilatory assist (NIV NAVA) supports ventilation postextubation in premature infants. Methods  A retrospective analysis of a cohort of twenty-four former VLBW ( 2 after increasing NAVA support was used as a marker for adequately supported noninvasive ventilation. The Wilcoxon signed-rank test was used to compare pre- and post-NAVA intervention (α = 0.05). Results  Ventilation improved after an increase in NIV NAVA level in 83% of the premature infants studied (20/24) with a decrease in median pCO 2 by 5 mm Hg ( p  = 0.0001). Conclusion  NIV NAVA can provide synchronized postextubation ventilatory support as measured by decreased pCO 2 in premature infants.