Effect of acute and chronic injections of amphetamine on intracranial self-stimulation (ICS) and some aryl alkyl amines in the rat brain

Abstract A single injection of amphetamine was shown to reduce the para tyramine concentration in the striatum and olfactory tubercles; meta tyramine values on the other hand increased. After chronic treatment, this pattern persisted with respect to meta tyramine in the striatum and para tyramine in the olfactory tubercles. In the striatum the para tyramine returned towards the endogenous value. No effect on these two trace amines was observed in the hypothalamus or hippocampus nor were significant changes noted in any region with respect to β-phenylethylamine. A direct relationship between para tyramine concentration and amphetamine-induced ICS and tolerance was demonstrated.