A new chemical tool for exploring the physiological function of the PDE2 isozyme

Robert J. Chambers,Kristin Abrams,Norman Y. Garceau,Ajith V. Kamath,Christopher M. Manley,Susan C. Lilley,Douglas A. Otte,Dennis O. Scott,Alissa L. Sheils,David A. Tess,A. Samuel Vellekoop,Yan Zhang,Kelvin Lam

A new chemical tool for exploring the physiological function of the PDE2 isozyme

2006

Robert J. Chambers
Kristin Abrams
Norman Y. Garceau
Ajith V. Kamath
Christopher M. Manley
Susan C. Lilley
Douglas A. Otte
Dennis O. Scott
Alissa L. Sheils
David A. Tess
A. Samuel Vellekoop
Yan Zhang
Kelvin Lam

Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.

Keywords:

ADME
Isozyme
Organic chemistry
Phosphoric Diester Hydrolases
Biochemistry
Chemistry
Oxindole
physiological function

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