Anaphylactoid purpura in children (Schonlein-Henoch syndrome): review with a follow-up of the renal complications.

Introduction Over 150 years have passed since Heberden 1 and Willan 2 first described patients with peculiar visceral crises associated with purpura and edema of the feet and hands. This striking syndrome has interested many investigators. Schonlein 3 described the arthritic component associated with purpura in 1837, calling it "peliosis rheumatica"; Henoch 4 added his classic description of four children with skin lesions associated with colicky abdominal pain, gastrointestinal hemorrhage, and joint pain in 1874; and Osler, 5-8 in a series of articles between 1895 and 1914 characterized it as a disease entity with variable symptoms, all of which he felt were the result of anaphylaxis. The term "anaphylactoid" purpura was first used by Frank 9 in 1915, and this idea was developed further by Glanzmann 10 in 1920. Sixty years ago, Henoch 11 noted that renal involvement was an important part of this type of purpura, and several years