[Epstein-Barr virus infection and expression of latent membrane protein 2A in Hodgkin's lymphoma of Uygur patients].

Objective To investigate Epstein-Barr virus (EBV) infection in Hodgkin's lymphoma (HL) of Uygur patients and related clinicopathological characteristics.Methods EBV-encoded small RNA (EBER) was detected in 40 cases of HL and 20 cases of lymphoid reactive hyperplasia by in-situ hybridization.Expression of LMP2A in HL was investigated by immunohistochemistry.Results EBV was detected in 26/40(65.0％) of HL and 5/20 of lymphoid reactive hyperplasia (P ＜ 0.05).The expression level of EBER showed significant difference among various histological subtypes of HL (P ＜ 0.05) and between patients with and without B symptom (P =0.02).However,no difference was found in relation to gender,clinical stage and tumor burden.The expression of LMP2A in the mixed cellularity and nodular sclerosis classical HL associated with EBV infection was 57.7％ (15/26).Expression of LMP2A was not detected in lymphoid reactive hyperplasia cases.Conclusion Uyghur patients with Hodgkin's lymphoma have a high infection rate of EBV and distinct clinicopathologic characteristics. Key words: Hodgkin disease ;  Herpesvirus 4, human;  In situ hybridization; Immunohistochemistry