Methods to induce cell tolerance ta tissue graft or organ.

SHOWN methods of inducing cell tolerance TA tissue graft or organ TRANSPLANT RECIPIENT OF. The methods involve administering to the patient: 1) a cell allogeneic or xenogeneic EXPRESSING donor antigens and which has a ligand on the cell surface that interacts with a receptor on the surface of a cell T RECIPIENT AND MAKING OF MEDIATOR IN THE ROLE OF DETERMINING THE AUXILIARY CONTACT DEPENDENT; And 2) receptor antagonist that inhibits ligand interaction with the receptor. In the preferred embodiment, the cell allogeneic or xenogeneic is a cell B, preferably a cell B IDLE, AND SURFACE molecule on T cell mediating ROLE OF DETERMINING THE AUXILIARY CONTACT IS DEPENDENT GP39. Antagonist GP39 preferred is an anti-GP39. CELL allogeneic or xenogeneic GP39 and antagonist are typically administered to a person BEFORE TRANSPLANTATION TRANSPLANTATION tissue or organ. METHODS OF THE INVENTION MAY BE USED TO INDUCE TOLERANCE CELL TRANSPLANTS TA such as liver, kidney, heart, lung, skin, muscle, NEURONAL TISSUE, stomach and intestine. ALSO it IS SHOWN A METHOD TO TREAT DIABETES involves the administration to a subject allogeneic or xenogeneic expressing donor antigens, an antagonist GP39 E ISLETAS PANCREATIC.