A highly enantioselective catalyst for asymmetric hydroformylation of [2.2.1]-bicyclic olefins

Abstract Rh(CO) 2 (acac)/TangPhos was found to be a highly enantioselective catalyst for asymmetric hydroformylation of norbornylene under mild conditions. Application of the protocol to the desymmetrization of other [2.2.1]-bicyclic olefins gave moderate to excellent enantioselectivity (55–92% ee).