Effect of Sub-Chronic Administration of Uand Dee Sweet Bitter Herbal Supplement on the Accessory Sex Organs of Male Wistar Rats

2 Abstract: The study investigated the effects of sub-chronic administration of UandDee Sweet bitter herbal supplement on the accessory sex organs of male wistar rats. Twenty male wistar rats were allocated to four dose groups of five rats each namely 0.00, 539, 1077, 1616mg/kg of the herbal product orally for 90 days. Animals had access to deionized water and were fed ad libitum with rat chow for 90 days. The feed and fluid consumption of the animals were measured on daily basis while the body weight was measured weekly. Animals were anaesthetized after 90 days, bled-sacrificed; epididymis (E), seminal vesicle (SV) and prostate (P) were excised and weighed, protein, DNA, epididymal sperm counts (ESC) were also determined. There was non-significant increase (p> 0.05) in feed and fluid intake and a significant decrease (p<0.05) in absolute and relative weights of the E, SV and P in all the treated animals when compared with the control. There were significant (p 0.05) decreases in ESC, DNA and protein levels in all the treated animals when compared with the control. The present work suggests that UandD sweet bitter herbal supplement may be toxic to the accessory sex organs of male wistar rats.