Vascular embolization device, and a method of manufacturing the same

In vascular embolization device having the anti-expansion lines in the primary shape coil, the anti-expansion lines, at least 1 Soyu and the core layer, one or more of the resin composition and an outer layer containing the biochemical active substance a multilayer line, vascular embolization device which core layer is configured such that the rupture strength is higher material tensile than the outer layer. Blood vessel embolization device has a function to administer a biochemical active substance, and has excellent flexibility.