Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
2009
To evaluate internal tandem duplication (ITD) insertion sites and length as well as their clinical impact in younger adult patients with FLT3 -ITD–positive acute myeloid leukemia (AML), sequencing after DNA-based amplification was performed in diagnostic samples from 241 FLT3 -ITD–mutated patients. All patients were treated on 3 German-Austrian AML Study Group protocols. Thirty-four of the 241 patients had more than 1 ITD, leading to a total of 282 ITDs; the median ITD length was 48 nucleotides (range, 15-180 nucleotides). ITD integration sites were categorized according to functional regions of the FLT3 receptor: juxtamembrane domain (JMD), n = 148; JMD hinge region, n = 48; beta1-sheet of the tyrosine kinase domain-1 (TKD1), n = 73; remaining TKD1 region, n = 13. ITD length was strongly correlated with functional regions ( P ), and AMLSG 07-04 ([NCT00151242][2]; ).
[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00146120&atom=%2Fbloodjournal%2F114%2F12%2F2386.atom
[2]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00151242&atom=%2Fbloodjournal%2F114%2F12%2F2386.atom
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