Effect of Resveratrol against Cisplatin-Induced Clastogenicity

Cisplatin (cDDP) is a widely used chemotherapeutic agent for treating a variety of cancers. The drug can also induce chromosomal aberrations (clastogenicity) in healthy cells in cancer patients. Resveratrol (RES) is a natural polyphenol and has been claimed that it has a high protection against clastogenicity. In this study, we aimed to investigate the effect of resveratrol on cDDP-induced chromosome aberrations in bone marrow cells of Wistar albino male rats. Six groups with six animals in each were orginized. Two different resveratrol doses (12.5 ve 25 mg/kg bw) were used and injected intraperitoneally (ip). Resveratrol doses were applied 5 times during the 24 h study period to coincide with the schedule for the cDDP-RES combination groups. With regard to the experimental schedule, cDDP-RES groups received cDDP (5 mg/kg bw) and RES at either 12.5 or 25 mg/kg bw, 30 min before, concurrently, and then at every 6 h after cDDP administration. RES caused a significant reduction in the frequency of chromosome aberrations compared to those induced with cDDP alone. As a result, repeatedly applied RES doses (12.5 or 25 mg/kg bw) during 24h caused statistically significant reduction at the frequency of cisplatin induced chromosome aberrations. In conclusion, it is evaluated that resveratrol can be an option as an adjuvant treatment.