IL-17A moonlighting in lung type 2 immunity
2020
Both Type 2 inflammation and the cytokine IL-17A are implicated
in allergic asthma, yet how these distinct immune responses are
interlinked in the lung remains poorly understood. Utilizing
helminth infection models in mice to induce pulmonary Type 2
immunity, Ajendra et al. reveal a molecular switch, where IL-17A
initially acts to promote the establishment of the Type 2 response
to infection by inhibiting IFNγ production, but at later stages IL-
17A acts to reduce Type 2 responses, protecting the lung tissue
from detrimental chronic inflammation. Interestingly, the multitasking
function of IL-17A in regulating lung Type 2 inflammation
was even observed when mice were infected with a different
helminth species that resides entirely in the gastrointestinal tract.
These novel findings advance our understanding of how IL-17A
plays multiple “moonlighting” functions in regulating pulmonary
Type 2 inflammation, which has implications for the etiology of
severe asthma.
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